The genetic architecture of structural left–right asymmetry of the human brain

Z Sha, D Schijven, A Carrion-Castillo, M Joliot… - Nature human …, 2021 - nature.com
Left–right hemispheric asymmetry is an important aspect of healthy brain organization for
many functions including language, and it can be altered in cognitive and psychiatric …

Evolution of Human Brain Left–Right Asymmetry: Old Genes with New Functions

J Wang, S Ma, P Yu, X He - Molecular Biology and Evolution, 2023 - academic.oup.com
The human brain is generally anatomically symmetrical, boasting mirror-like brain regions in
the left and right hemispheres. Despite this symmetry, fine-scale structural asymmetries are …

Mapping brain asymmetry in health and disease through the ENIGMA consortium

XZ Kong, MC Postema, T Guadalupe… - Human brain …, 2022 - Wiley Online Library
Left–right asymmetry of the human brain is one of its cardinal features, and also a complex,
multivariate trait. Decades of research have suggested that brain asymmetry may be altered …

Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains

CGF De Kovel, SN Lisgo, SE Fisher, C Francks - Scientific reports, 2018 - nature.com
Left-right laterality is an important aspect of human–and in fact all vertebrate–brain
organization for which the genetic basis is poorly understood. Using RNA sequencing data …

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

XZ Kong, SR Mathias, T Guadalupe… - Proceedings of the …, 2018 - National Acad Sciences
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain
asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the …

Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles

K Saltoun, R Adolphs, LK Paul, V Sharma… - Nature Human …, 2023 - nature.com
Broca reported~ 150 years ago that particular lesions of the left hemisphere impair speech.
Since then, other brain regions have been reported to show lateralized structure and …

Mapping brain asymmetry

AW Toga, PM Thompson - Nature Reviews Neuroscience, 2003 - nature.com
Brain asymmetry has been observed in animals and humans in terms of structure, function
and behaviour. This lateralization is thought to reflect evolutionary, hereditary …

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

T Guadalupe, SR Mathias, TGM Vanerp… - Brain imaging and …, 2017 - Springer
The two hemispheres of the human brain differ functionally and structurally. Despite over a
century of research, the extent to which brain asymmetry is influenced by sex, handedness …

Molecular approaches to cerebral laterality: development and neurodegeneration

DH Geschwind, BL Miller - American journal of medical …, 2001 - Wiley Online Library
Little is understood about the genetic or epigenetic mechanisms that underlie brain
asymmetry. Because higher cognitive functions such as language, constructional and spatial …

Heritability and cross-species comparisons of human cortical functional organization asymmetry

B Wan, Ş Bayrak, T Xu, HL Schaare, RAI Bethlehem… - Elife, 2022 - elifesciences.org
The human cerebral cortex is symmetrically organized along large-scale axes but also
presents inter-hemispheric differences in structure and function. The quantified contralateral …