Myostatin–the holy grail for muscle, bone, and fat?
B Buehring, N Binkley - Current osteoporosis reports, 2013 - Springer
Myostatin, a member of the transforming growth factor beta (TGF-β) superfamily, was first
described in 1997. Since then, myostatin has gained growing attention because of the …
described in 1997. Since then, myostatin has gained growing attention because of the …
Myostatin: Basic biology to clinical application
P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
The central role of myostatin in skeletal muscle and whole body homeostasis
Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …
plays a key role in skeletal muscle homeostasis and has now been well described since its …
Myostatin: more than just a regulator of muscle mass
The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
[HTML][HTML] Expression and function of myostatin in obesity, diabetes, and exercise adaptation
DL Allen, DS Hittel, AC McPherron - Medicine and science in …, 2011 - ncbi.nlm.nih.gov
Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …
Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease
Y Cui, Q Yi, W Sun, D Huang, H Zhang, L Duan… - Biofactors, 2023 - Wiley Online Library
Myostatin, a member of the transforming growth factor‐β (TGF‐β) superfamily, is a key
autocrine/paracrine inhibitor of skeletal muscle growth. Recently, researchers have …
autocrine/paracrine inhibitor of skeletal muscle growth. Recently, researchers have …
Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise
MW Hamrick, T Samaddar, C Pennington… - Journal of bone and …, 2006 - academic.oup.com
We tested the hypothesis that increased muscle mass augments increases in bone strength
normally observed with exercise. Myostatin‐deficient mice, which show increased muscle …
normally observed with exercise. Myostatin‐deficient mice, which show increased muscle …
Myostatin: expanding horizons
M Sharma, C McFarlane, R Kambadur, H Kukreti… - IUBMB …, 2015 - Wiley Online Library
Myostatin is a secreted growth and differentiation factor that belongs to the TGF‐β
superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and …
superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and …
[HTML][HTML] Deciphering myostatin's regulatory, metabolic, and developmental influence in skeletal diseases
CL Omosule, CL Phillips - Frontiers in Genetics, 2021 - frontiersin.org
Current research findings in humans and other mammalian and non-mammalian species
support the potent regulatory role of myostatin in the morphology and function of muscle as …
support the potent regulatory role of myostatin in the morphology and function of muscle as …
[HTML][HTML] Myostatin inhibitors: panacea or predicament for musculoskeletal disorders?
J Suh, YS Lee - Journal of bone metabolism, 2020 - ncbi.nlm.nih.gov
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …