We have recently reported that the adenylate cyclase activator, forskolin, induces in the rat
ovarian follicle both cAMP accumulation and oocyte maturation. We demonstrate here, on …

Forskolin, a reversible stimulator of the catalytic subunit of adenylate cyclase, has been used
to determine:(1) whether an increase in hamster cumulus cell cyclic adenosine …

The diterpene forskolin, which was found to be a potent and reversible activator of adenylate
cyclase in intact tissues as well as in broken cell preparations, was employed to investigate …

Oocytes isolated from mature follicles undergo spontaneous maturation when cultured in
vitro. Forskolin, an adenylate cyclase stimulator, inhibited resumption of meiosis of cumulus …

The adenylate cyclase activator forskolin was used to study the role of cAMP for oocyte
meiosis and follicular steroid secretion. Follicular and cumulus cAMP production was …

The hypothesis that cumulus cells inhibit oocyte maturation by a cAMP-dependent process
was tested (RM Schultz, R. Montgomery, PF Ward-Bailey, and JJ Eppig (1983). Dev. Biol …

Forskolin (0–100 μ m), a reversible stimulator of the catalytic subunit of adenylate cyclase,
induced dose—response increases in the% germinal vesicle (GV)(ID 50= 2· 68 μ m, where …

This study was undertaken to analyse the time relationships between breakdown of
communication in the cumulus-oocyte complex and reinitiation of meiosis in the oocyte. In …

The effect in vitro of oocyte maturation inhibitors and the ability of preparations of luteinizing
hormone to relieve the arrest induced by these substances was studied in preparations of …

The involvement of cyclic adenosine monophosphate (cAMP) in mammalian oocyte
maturation was assessed using cultures of rabbit cumulus–oocyte complexes and perfused …