Chronic myeloid leukemia (CML) is a stem cell disease of the bone marrow where
mechanisms of inter-leukemic communication and cell-to-cell interactions are proposed to …

Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular
communication in the leukemic bone marrow participates in disease development …

Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …

Intercellular communication within the bone marrow niche significantly promotes
leukemogenesis and provides protection of leukemic cells from therapy. Secreted factors …

Simple Summary Tunneling nanotubes (TNTs) are cytoplasmic channels which regulate the
contacts between cells and allow the transfer of several elements, including ions …

Acute lymphoblastic leukemia (ALL) cells disrupt the healthy bone marrow
microenvironment to create a leukemic niche that is crucial for facilitating leukemogenesis …

Tumor-associated macrophages (TAMs) secrete cytokines, chemokines, and growth factors
in the tumor microenvironment (TME) to support cancer progression. Higher TAM infiltration …

Intercellular communication within the tumor microenvironment (TME) is essential for
establishing, mediating, and synchronizing cancer cell invasion and metastasis. Cancer …

The interaction between tumor cells and macrophages is crucial in promoting tumor invasion
and metastasis. In this study, we examined a novel mechanism of intercellular …

Highlights•Hematopoietic progenitors are interconnected by F-actin-dependent TNTs.•Cell
dislodgement is the primary mechanism responsible for TNT biogenesis.•TNTs emerge from …