Abstract Lipid phosphate phosphatase 3 (LPP3) is a membrane-bound enzyme that
hydrolyzes lipid phosphates including the bioactive lipid, lysophosphatidic acid (LPA) …

Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in
circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated …

Abstract Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme
that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the …

Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride
synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and …

Lipid phosphate phosphatase 1 (LPP-1) is presumed to regulate the balance between lipid
phosphates and their dephosphorylated counterparts. The currently prevailing hypothesis …

Acute myocardial infarction (MI) leads to the activa-tion of a systemic inflammatory response,
which is imperative for tissue healing, but uncontrolled/prolonged inflammation is …

APPL1 (adaptor protein containing PH domain, PTB domain, and leucine zipper motif 1) has
been established as an important mediator of insulin and adiponectin signaling. Here, we …

2196 Journal of Lipid Research Volume 55, 2014 an elegant approach to determine the
extent to which observed decreases in responses to bioactive lipid phosphate agonists in …

Objective: Genome-wide association studies identified novel loci in PLPP3 (phospholipid
phosphatase 3) that associate with coronary artery disease risk independently of traditional …

Lipid phosphate phosphatases (LPP) are integral membrane proteins with broad substrate
specificity that dephosphorylate lipid substrates including phosphatidic acid …