Temperature is a ubiquitous environmental variable which can profoundly influence the
physiology of living cells as it changes over time and space. When yeast cells are exposed …

Thermal adaptation is essential in all organisms. In yeasts, the heat shock response is
commanded by the heat shock transcription factor Hsf1. Here we have integrated unbiased …

The major human fungal pathogen, Candida albicans, colonizes different body sites,
differing greatly in oxygen levels. Using whole-genome DNA microarrays, we analysed the …

Despite being obligately associated with warm-blooded animals, Candida albicans
expresses a bona fide heat shock response that is regulated by the evolutionarily …

Conditions in the infected human host trigger virulence attributes of the fungal pathogen
Candida albicans. Specific inducers and elevated temperatures lead to hyphal development …

Eukaryotic cells have evolved mechanisms to sense and adapt to dynamic environmental
changes. Adaptation to thermal insults, in particular, is essential for their survival. The major …

The balance between saturated and unsaturated fatty acids plays a crucial role in
determining the membrane fluidity. In the diploid fungal pathogen Candida albicans, the …

The regulation of the response of Candida albicans to hypoxic (low-oxygen) conditions is
poorly understood. We used microarray and other transcriptional analyses to investigate the …

The evolutionarily conserved heat shock transcription factor Hsf1 plays a central role in
thermal adaptation in the major fungal pathogen of humans, Candida albicans. Hsf1 …

Morphological transitions and metabolic regulation are critical for the human fungal
pathogen Candida albicans to adapt to the changing host environment. In this study, we …