Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia …

L Sun, J Fu, SH Lin, JL Sun, L Xia, CH Lin, L Liu… - Journal of Allergy and …, 2020 - Elsevier
Background Epidemiologic evidence suggests that exposure to particulate matter of 2.5 μm
or less in diameter (PM2. 5) aggravates asthma. Objective We sought to investigate the …

The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice

KL Huang, SY Liu, CCK Chou, YH Lee, TJ Cheng - PLoS One, 2017 - journals.plos.org
Background Particulate matter (PM) has been associated with increased pulmonary and
cardiovascular mortality and morbidity. Additionally, PM is known to exacerbate asthma …

Traffic-related PM2. 5 and diverse constituents disturb the balance of Th17/Treg cells by STAT3/RORγt-STAT5/Foxp3 signaling pathway in a rat model of asthma

C Wang, D Wang, H Zhao, J Wang, N Liu, H Shi… - International …, 2021 - Elsevier
Water-soluble ions (WSI) and organic extract (OE) in traffic-related particulate matter with
aerodynamic diameters≤ 2.5 μm (TRPM 2.5) are potential risk factors for asthma …

Exacerbating effects of PM2. 5 in OVA-sensitized and challenged mice and the expression of TRPA1 and TRPV1 proteins in lungs

H Liu, X Fan, N Wang, Y Zhang, J Yu - Journal of Asthma, 2017 - Taylor & Francis
Objective: To investigate the effects of particulate matter≤ 2.5 microns (PM2. 5) on asthma-
related phenotypes and on lung expression of TRPA1 and TRPV1 proteins in a mouse …

Ambient PM2. 5 exposure exacerbates severity of allergic asthma in previously sensitized mice

X Zhang, W Zhong, Q Meng, Q Lin, C Fang… - Journal of …, 2015 - Taylor & Francis
Objective: Epidemiological studies have shown that elevated concentrations of ambient
particulate matter (aerodynamic diameter≤ 2.5 μm; PM2. 5) correlates with increased …

Respiratory exposure to PM2. 5 soluble extract disrupts mucosal barrier function and promotes the development of experimental asthma

C Zhao, Y Wang, Z Su, W Pu, M Niu, S Song… - Science of The Total …, 2020 - Elsevier
Background Air pollutants are important factors that contribute to the development and
exacerbation of asthma, but experimental evidence still needs to be collected and the …

PM2. 5 exposure regulates Th1/Th2/Th17 cytokine production through NF-κB signaling in combined allergic rhinitis and asthma syndrome

CH Piao, Y Fan, T Van Nguyen, CH Song… - International …, 2023 - Elsevier
Background Particulate matter (PM) is a major component of air pollution from emissions
from anthropogenic and natural sources and is a serious problem worldwide due to its …

T-helper type 1-T-helper type 2 shift and nasal remodeling after fine particulate matter exposure in a rat model of allergic rhinitis

ZQ Guo, WY Dong, J Xu, ZC Hong… - American Journal of …, 2017 - journals.sagepub.com
Background Exposure to fine particulate matter (particulate matter≤ 2.5 μm [PM2. 5])
increases the risk of allergic rhinitis (AR), but the underlying mechanisms remains unclear …

Particulate matter–induced airway hyperresponsiveness is lymphocyte dependent

V Saunders, P Breysse, J Clark, A Sproles… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Exposure to airborne particulate matter (PM), a major component of air
pollution, has been associated with increases in both exacerbations of and hospitalizations …

Association between particulate matter containing EPFRs and neutrophilic asthma through AhR and Th17

JN Harding, M Gross, V Patel, S Potter… - Respiratory Research, 2021 - Springer
Background Epidemiological data associate high levels of combustion-derived particulate
matter (PM) with deleterious respiratory outcomes, but the mechanism underlying those …