We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is
associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this …

Alcohol consumption is largely associated with alterations in the extracellular glutamate
concentrations in several brain reward regions. We recently showed that glutamate …

Chronic ethanol exposure affects the glutamatergic system in several brain reward regions
including the nucleus accumbens (NAc). Our laboratory has shown that chronic exposure to …

Alteration of glutamatergic-neurotransmission is a hallmark of alcohol dependence. We
have previously reported that chronic ethanol-drinking downregulated glutamate transporter …

Chronic ethanol consumption is known to downregulate expression of the major glutamate
transporter 1 (GLT-1), which increases extracellular glutamate concentrations in subregions …

Previously, we have reported that cefazolin and cefoperazone treatments attenuated ethanol
consumption, at least in part, through upregulation of GLT-1 expression in male alcohol …

Alcohol dependence is associated with alteration of glutamate transport and glutamate
neurotransmission. Glutamate transporter 1 (GLT-1) is a major transporter that regulates the …

Aims: Changes in glutamatergic transmission affect many aspects of neuroplasticity
associated with ethanol and drug addiction. For instance, ethanol-and drug-seeking …

Relapse-like ethanol-drinking behavior depends on increased glutamate transmission in the
mesocorticolimbic motive circuit. Extracellular glutamate is regulated by a number of …

The metabotropic glutamate 5 receptor (mGlu5) receptor has been implicated as having a
role in pain modulation, anxiety, and depression, as well as drug-seeking behavior. In the …