In spite of there being a number of vaccines, influenza remains a significant global cause of
morbidity and mortality. Understanding more about natural and vaccine induced immune …

Despite long-term investment, influenza continues to be a significant worldwide problem.
The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a …

Influenza is a highly contagious viral respiratory disease that affects millions of people
worldwide each year. Annual vaccination is recommended by the World Health Organization …

BACKGROUND: Immunoglobulin A (IgA) is the predominant antibody produced in response
to mucosal infections. The role of IgA in providing protection against influenza in children …

Two different influenza vaccines are generally used in many countries; trivalent live
attenuated influenza vaccine (LAIV3) and trivalent inactivated influenza vaccine (IIV3) …

Influenza morbidity affects entire populations, imposing an enormous burden in economic
terms from working days lost. Protection afforded by current vaccines is often unsatisfactory …

Antibody titers are commonly used as surrogate markers for serological protection against
influenza and other pathogens. Detailed knowledge of antibody production pre-and post …

Background Serum antibody to influenza can be used to identify past exposure and
measure current immune status. The two most common methods for measuring this are the …

ABSTRACT A serum hemagglutination inhibition (HAI) titer of 40 or greater is thought to be
associated with reduced influenza virus pathogenesis in humans and is often used as a …

We investigated the cross-neutralising potential of serum and nasal wash samples from
volunteers who were intranasally immunised once with a monovalent replication-deficient …