Benzodiazepine use and hip fractures in the elderly: who is at greatest risk?

AK Wagner, F Zhang, SB Soumerai… - Archives of internal …, 2004 - jamanetwork.com
Background It remains unclear whether benzodiazepine use increases hip fracture
incidence. We studied this relationship in a large cohort, controlling for multiple potential …

Benzodiazepine and risk of hip fractures in older people: a nested case-control study in Taiwan

CM Chang, ECH Wu, IS Chang, KM Lin - The American journal of geriatric …, 2008 - Elsevier
Objective To examine the characteristics of benzodiazepines usage and their associations
with hip fractures. Method All subjects were aged 65 and older and enrolled in the National …

Effect of New York State regulatory action on benzodiazepine prescribing and hip fracture rates

AK Wagner, D Ross-Degnan, JH Gurwitz… - Annals of Internal …, 2007 - acpjournals.org
Background: Medicare Part D excludes benzodiazepines from coverage, and numerous
state government policies limit use of benzodiazepines. No data indicate that such policies …

Benzodiazepines and risk of hip fractures in older people: a review of the evidence

RG Cumming, DGL Conteur - CNS drugs, 2003 - Springer
A hip fracture epidemic is occurring in developed countries in association with population
aging. The increasing number of people with a hip fracture has major implications for …

Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture

PS Wang, RL Bohn, RJ Glynn… - American Journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: While benzodiazepine treatment is known to increase the risk of hip fracture in
older populations, controversy persists over which characteristics of benzodiazepine use …

Benzodiazepines of long and short elimination half-life and the risk of hip fracture

WA Ray, MR Griffin, W Downey - Jama, 1989 - jamanetwork.com
To determine if the risk of hip fracture differed between persons receiving benzodiazepines
with long (≥ 24 hours) or short (< 24 hours) elimination half-lives, we conducted a nested …

Benzodiazepines and the risk of falling leading to femur fractures: dosage more important than elimination half-life

RMC Herings, BHC Stricker, A de Boer… - Archives of Internal …, 1995 - jamanetwork.com
Background: In the past decade, the use of benzodiazepines has been identified as a major
independent risk factor for accidental falls. Objective: To study the role of dosing, timing …

Impact of drug interactions, dosage, and duration of therapy on the risk of hip fracture associated with benzodiazepine use in older adults

K Zint, WE Haefeli, RJ Glynn, H Mogun… - … and drug safety, 2010 - Wiley Online Library
Purpose To determine how concomitant use of potentially interacting drugs, drug dosage,
and duration of therapy modify the risk of hip fracture associated with use of …

Association between benzodiazepines use and risk of hip fracture in the elderly people: A meta-analysis of observational studies

TN Poly, MM Islam, HC Yang, YCJ Li - Joint Bone Spine, 2020 - Elsevier
Objective Hip fracture is one of the leading causes of disability, cost, morbidity, and mortality.
Several studies reported that benzodiazepines (BDZs) have been associated with an …

Benzodiazepines and hip fractures in elderly people: case-control study

C Pierfitte, G Macouillard, M Thicoïpe, A Chaslerie… - Bmj, 2001 - bmj.com
Objective: To determine whether benzodiazepines are associated with an increased risk of
hip fracture. Design: Case-control study. Participants: All incident cases of hip fracture not …