New blood vessel formation in transplanted islets occurs within 7–14 days post‐
transplantation through both the expansion of donor islet endothelium and ingrowth of blood …

The blood vessels of the pancreatic islets are of crucial importance for oxygen and
metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …

Rapid reestablishment of a functional microvasculature in transplanted islets is crucial for
islet survival and function. To illustrate the importance of angiogenesis in islet engraftment …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen with potent
angiogenic and vascular permeability-inducing properties, both of which may be important …

Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

Previously, we have found that human islets experimentally transplanted beneath the kidney
capsule have lower vascular density than native islets. This study aimed to investigate …

Transplantation of pancreatic islets is proposed as a treatment for type 1 diabetes, but
insufficient blood supply can cause the loss of viable grafted islets. In the present study, we …