The progress of islet transplantation as a new therapy for patients with diabetes mellitus
depends directly upon the development of efficient and practical immunoisolation methods …

During pancreatic islet transplantation, delayed and insufficient revascularization can
deprive islets of oxygen and nutrients, resulting in cell death and early graft failure …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

Although the microvascular endothelium has been identified as the primary target site for the
initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular …

OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet
endothelial cells (ECs), which can contribute to the formation of functional blood vessels …

Beta cell replacement is an exciting field where new beta cell sources and alternative sites
are widely explored. The liver has been the implantation site of choice in the clinic since the …

Vascularization of transplanted islets must be maintained to provide long‐term graft function.
In vivo assessment of new vessel formation in islet grafts has been poorly documented. The …

Endogenous pancreatic islets have a dense glomerular-like angioarchitecture, which
ensures an optimal delivery of oxygen and nutrients to the islet cells, provides signals from …

There is evidence that intraislet cellular communication and hormone delivery within the
islets of Langerhans is controlled via capillary perfusion directed from the B cell core to the …