Radiotherapy (RT) is a traditional and important treatment for carcinoma of the esophagus
along with surgery and chemotherapy. High mobility group box 1 (HMGB1) plays a crucial …

Esophageal cancer is a common malignant disease that is generally treated with
radiotherapy. High mobility group box 1 (HMGB1) plays an essential role in tumor cell …

Background To explore the effect of HMGB1 on the radio-sensitivity of esophageal cancer
cells through regulating the PI3K/Akt/ATM pathway. Methods and results We observed the …

Abstract Background and Aim The high‐mobility group box 1 (HMGB1) protein plays an
important role in a lot of biological behaviors, including DNA damage repair, gene …

Radiotherapy is an effective therapeutic strategy in esophageal squamous cell carcinoma
(ESCC). However, acquired radioresistance of cancer cells leads to radiotherapy failure …

Overexpression of high-mobility group box 2 (HMGB2) is recently reported in several
malignant cancers and was correlated with poor response to preoperative …

Resistance to radiotherapy results in relapse and treatment failure in locally advanced
esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is …

Introduction HMGB1 (High mobility group box 1), originally described as a nuclear protein, is
now regarded as a multifunctional protein with a paradoxical dual effect in tumors. In the …

High‐mobility group box 1 (HMGB1) is a multifunctional protein with intranuclear and
extracellular functions. Although HMGB1 is overexpressed in approximately 85% of gastric …

Rectal cancer is a malignant gastrointestinal tumor, which is associated with high morbidity
and mortality. High‑mobility group protein 1 (HMGB1) is widely present in the nucleus of …