At birth, lung fluid clearance is coupled to Na+ transport through epithelial Na+ channels
(ENaC) in the distal lung epithelium. We evaluated the effect of postnatal glucocorticoids …

Glucocorticoid hormones play an important role in fetal lung maturation. It is unknown how
they interact with changes in O2 tension, which play an important role in converting the lung …

Lung liquid absorption at birth is crucial for the successful onset of respiration. Na absorption
by the renal collecting duct plays an important role in renal fluid and electrolyte homeostasis …

Pulmonary epithelial Na+ channels (ENaC), composed of three distinct subunits (alpha,
beta, and gamma), play a critical role in the regulation of fluid reabsorption from airspaces of …

BACKGROUND: Glucocorticoids have profound effects on lung maturation and function. In
in vitro and animal models, they induce epithelial sodium channels (ENaCs) in the airway …

Background: The airway epithelial sodium channel (ENaC) is rate limiting for postnatal
alveolar fluid clearance. Increased lung water content is a feature of respiratory distress …

Purpose Glucocorticoids and progesterone exert stimulatory effects on epithelial Na+
transport, including increased mRNA expression of the participating ion transporters …

Transition of the epithelium of the fetal lung from fluid secretion to fluid reabsorption requires
changes in the expression of ion channels. Corticosteroids regulate expression of several of …

We have studied factors that potentially modulate the expression of mRNA coding for
subunits of the amiloride‐sensitive sodium channel, αENaC and βENaC, in lungs of …

The epithelial Na channel (ENaC) plays a critical role in the active reabsorption of alveolar
fluid at the time of birth or during pulmonary edema. Although rat (r) ENaC is regulated by …