RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …

We present in vivo sequence-specific RNA base editing via adenosine deaminases acting
on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we …

One of the most prevalent forms of post-transcriptional RNA modification is the conversion of
adenosine-to-inosine (A-to-I), mediated by adenosine deaminase acting on RNA (ADAR) …

Adenosine deaminases acting on RNA (ADARs) can be repurposed to enable
programmable RNA editing, however their exogenous delivery leads to transcriptome-wide …

Site-directed RNA editing might provide a safer or more effective alternative to genome
editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of …

Current tools for targeted RNA editing rely on the delivery of exogenous proteins or
chemically modified guide RNAs, which may lead to aberrant effector activity, delivery …

Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …

RNA base editing represents a promising alternative to genome editing. Recent approaches
harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA …

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …

RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …