κ‐Opioid receptor‐mediated enhancement of the hyperpolarization‐activated current (Ih) through mobilization of intracellular calcium in rat nucleus raphe magnus

ZZ Pan - The Journal of Physiology, 2003 - Wiley Online Library
The hyperpolarization‐activated current (Ih) is important in the control of resting membrane
potential, in the regulation of network firing pattern and in the modulation of presynaptic …

Opioids act at μ-receptors to hyperpolarize arcuate neurons via an inwardly rectifying potassium conductance

MD Loose, MJ Kelly - Brain research, 1990 - Elsevier
Intracellular recordings were made from 48 hypothalamic arcuate (ARC) neurons under
current-and voltage-clamp in slices prepared from female guinea pigs which had been …

Antagonizing effect of protein kinase C activation on the μ-opioid agonist-induced inhibition of high voltage-activated calcium current in rat periaqueductal gray neuron

YW Cho, SH Han, BI Min, JS Rhee, N Akaike - Brain research, 2001 - Elsevier
Opioids have been thought to induce analgesia by activating the descending pain control
system, especially at the level of periaqueductal gray, and regulate the neurotransmitter …

Direct Inhibition of Ih by Analgesic Loperamide in Rat DRG Neurons

DV Vasilyev, Q Shan, Y Lee… - Journal of …, 2007 - journals.physiology.org
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are responsible for the
functional hyperpolarization-activated current (I h) in dorsal root ganglion (DRG) neurons …

Suppression of Ih Contributes to Propofol-Induced Inhibition of Mouse Cortical Pyramidal Neurons

X Chen, S Shu, DA Bayliss - Journal of neurophysiology, 2005 - journals.physiology.org
The contributions of the hyperpolarization-activated current, I h, to generation of rhythmic
activities are well described for various central neurons, particularly in thalamocortical …

Expression and properties of hyperpolarization‐activated current in rat dorsal root ganglion neurons with known sensory function

LL Gao, S McMullan, L Djouhri, C Acosta… - The Journal of …, 2012 - Wiley Online Library
Key point• I h is a hyperpolarisation‐activated current that influences neuronal excitability
and is present in some sensory neurons.• The magnitude and properties of Ih in different …

Single channel properties of hyperpolarization‐activated cation currents in acutely dissociated rat hippocampal neurones

TA Simeone, JM Rho, TZ Baram - The Journal of Physiology, 2005 - Wiley Online Library
The hyperpolarization‐activated cation current (Ih), mediated by HCN channels, contributes
to intrinsic neuronal properties, synaptic integration and network rhythmicity. Recent studies …

Effect of catecholamines on the hyperpolarization‐activated cationic Ih and the inwardly rectifying potassium IKir currents in the rat substantia nigra pars compacta

L Cathala, D Paupardin‐Tritsch - European Journal of …, 1999 - Wiley Online Library
Whole‐cell ruptured‐patch and perforated‐patch recordings were used in principal neurons
of the rat substantia nigra pars compacta (SNc) to study the effect of catecholamines both on …

Hyperpolarization by opioids acting on μ‐receptors of a sub‐population of rat periaqueductal gray neurones in vitro

B Chieng, MJ Christie - British journal of pharmacology, 1994 - Wiley Online Library
1 The actions of opioids on membrane properties of rat periaqueductal gray neurones were
investigated using intracellular recordings from single neurones in brain slices …

κ-and μ-Opioid inhibition of N-type calcium currents is attenuated by 4β-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons

APJ King, KE Hall, RL Macdonald - Journal of Pharmacology and …, 1999 - ASPET
In rat dorsal root ganglion neurons, activation of κ-and μ-opioid receptors decreases N-type
calcium current, whereas a constitutively active form of protein kinase C (PKC; ie, PKM, a …