Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury
Mild traumatic brain injuries (TBIs) comprise three-quarters of all TBIs occurring in the United
States annually, and psychological symptoms arising from them can last years after injury …
States annually, and psychological symptoms arising from them can last years after injury …
Injury severity differentially alters sensitivity to dexamethasone after traumatic brain injury
AN Taylor, SU Rahman, DL Tio, SM Gardner… - Journal of …, 2010 - liebertpub.com
We have reported differential short-and long-term dysregulation of the neuroendocrine
stress response after traumatic brain injury (TBI) produced by controlled cortical impact …
stress response after traumatic brain injury (TBI) produced by controlled cortical impact …
Restoration of Neuroendocrine Stress Response by Glucocorticoid Receptor or GABAA Receptor Antagonists after Experimental Traumatic Brain Injury
AN Taylor, DL Tio, RL Sutton - Journal of neurotrauma, 2013 - liebertpub.com
We previously reported that traumatic brain injury (TBI) produced by moderate controlled
cortical impact (CCI) attenuates the stress response of the hypothalamic-pituitary-adrenal …
cortical impact (CCI) attenuates the stress response of the hypothalamic-pituitary-adrenal …
Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury
MA Taylor, ON Kokiko-Cochran - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and
psychiatric consequences that can persist long after injury. TBI induces a physiological …
psychiatric consequences that can persist long after injury. TBI induces a physiological …
The blockade of corticotropin-releasing factor 1 receptor attenuates anxiety-related symptoms and hypothalamus–pituitary–adrenal axis reactivity in mice with mild …
M Kosari-Nasab, T Sadeghi, H Bashiri… - Behavioural …, 2019 - journals.lww.com
Recent studies have shown that mild traumatic brain injury (mTBI) is associated with higher
risk for anxiety-related disorders. Dysregulation in the hypothalamus–pituitary–adrenal …
risk for anxiety-related disorders. Dysregulation in the hypothalamus–pituitary–adrenal …
Glucocorticoids are required for extinction of predator stress-induced hyperarousal
R Clay, M Hebert, G Gill, LA Stapleton… - Neurobiology of learning …, 2011 - Elsevier
BACKGROUND: The role of glucocorticoids in extinction of traumatic memories has not
been fully characterized despite its potential as a therapeutic target for acquired …
been fully characterized despite its potential as a therapeutic target for acquired …
Glucocorticoids protect against the delayed behavioral and cellular effects of acute stress on the amygdala
RP Rao, S Anilkumar, BS McEwen, S Chattarji - Biological psychiatry, 2012 - Elsevier
BACKGROUND: A single episode of acute immobilization stress has previously been shown
to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …
to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral …
Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampus
DL McCullers, PG Sullivan, SW Scheff, JP Herman - Brain research, 2002 - Elsevier
Glucocorticoid activation of two types of adrenocorticosteroid receptors (ACRs), the
mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), influences the …
mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), influences the …
Effects of acute restraint-induced stress on glucocorticoid receptors and brain-derived neurotrophic factor after mild traumatic brain injury
GS Griesbach, J Vincelli, DL Tio, DA Hovda - Neuroscience, 2012 - Elsevier
We have previously reported that experimental mild traumatic brain injury results in
increased sensitivity to stressful events during the first post-injury weeks, as determined by …
increased sensitivity to stressful events during the first post-injury weeks, as determined by …
Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats
LC Fox, JL Scholl, GM Palmer, GL Forster… - Experimental …, 2023 - Elsevier
Mild traumatic brain injuries (mild TBIs) commonly occur in young adults of both sexes,
oftentimes in high-stress environments. In humans, sex differences have been observed in …
oftentimes in high-stress environments. In humans, sex differences have been observed in …