Membrane-targeting approaches for enhanced cancer cell destruction with irreversible electroporation

C Jiang, Z Qin, J Bischof - Annals of biomedical engineering, 2014 - Springer
Irreversible electroporation (IRE) is a promising technology to treat local malignant cancer
using short, high-voltage electric pulses. Unfortunately, in vivo studies show that IRE suffers …

Pulse timing during irreversible electroporation achieves enhanced destruction in a hindlimb model of cancer

C Jiang, Q Shao, J Bischof - Annals of biomedical engineering, 2015 - Springer
The use of irreversible electroporation (IRE) for cancer treatment has increased during the
past decade due to many advantages over other focal therapies. However, despite early …

Synergistic combinations of short high-voltage pulses and long low-voltage pulses enhance irreversible electroporation efficacy

C Yao, Y Lv, Y Zhao, S Dong, H Liu, J Ma - Scientific reports, 2017 - nature.com
Abstract Irreversible electroporation (IRE) uses~ 100 μs pulsed electric fields to disrupt cell
membranes for solid tumor ablation. Although IRE has achieved exciting preliminary clinical …

Mathematical modeling of irreversible electroporation for treatment planning

JF Edd, RV Davalos - Technology in cancer research & …, 2007 - journals.sagepub.com
Irreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of
particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a …

Electrode activation sequencing employing conductivity changes in irreversible electroporation tissue ablation

AV Sahakian, HM Al-Angari… - IEEE transactions on …, 2011 - ieeexplore.ieee.org
Irreversible electroporation (IRE) uses high-voltage pulses applied to tissue, which cause
dielectric breakdown of cell membranes resulting in cell death. IRE is a promising technique …

Physical and chemical enhancement of and adaptive resistance to irreversible electroporation of pancreatic cancer

Q Shao, F Liu, C Chung, K Elahi-Gedwillo… - Annals of biomedical …, 2018 - Springer
Irreversible electroporation (IRE) can be used to treat cancer by electrical pulses, with
advantages over traditional thermal approaches. Here we assess for the first time the IRE …

A 2-D cell layer study on synergistic combinations of high-voltage and low-voltage irreversible electroporation pulses

Y Lv, C Yao, B Rubinsky - IEEE Transactions on Biomedical …, 2019 - ieeexplore.ieee.org
Irreversible electroporation (IRE) employs brief, high-electric field pulses to ablate tumors
while preserving the extracellular matrix. Recently, we showed that combining short high …

Bursts of bipolar microsecond pulses inhibit tumor growth

MB Sano, CB Arena, KR Bittleman, MR DeWitt… - Scientific reports, 2015 - nature.com
Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility
in the treatment of unresectable tumors where thermal ablation techniques are …

Chemical enhancement of irreversible electroporation: A review and future suggestions

Y Chen, MAJ Moser, Y Luo… - Technology in Cancer …, 2019 - journals.sagepub.com
Irreversible electroporation has raised great interest in the past decade as a means of
destroying cancers in a way that does not involve heat. Irreversible electroporation is a novel …

Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by “electric field sinks”

A Golberg, BG Bruinsma, BE Uygun, ML Yarmush - Scientific reports, 2015 - nature.com
Irreversible electroporation (IRE) is an emerging, minimally invasive technique for solid
tumors ablation, under clinical investigation for cancer therapy. IRE affects only the cell …