The protein C anticoagulant pathway serves as a major system for controlling thrombosis,
limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in …

The goals of this chapter are to provide a brief review of the biology of the protein C pathway
and some of the features of the pathway that make it uniquely positioned to control …

Activated protein C (APC) supplementation significantly reduces mortality in patients with
severe sepsis, presumably by down-regulating coagulation, inflammation, and apoptosis. In …

Thrombin is a multifunctional protein, with procoagulant, inflammatory and anticoagulant
effects. Binding of thrombin to thrombomodulin results in activation of Protein C and initiation …

After a coagulation stimulus, the blood clotting cascade amplifies largely unchecked until
very high levels of thrombin are generated. Natural anticoagulant mechanisms (for example …

Objective To delineate critical differences between activated protein C (APC) and its
precursor, protein C, with regard to plasma levels in health and in severe sepsis, and to …

Objective: To review new findings about the function of the protein C system during
inflammation and coagulation. Main Findings: Coagulation proteases and their cofactors …

The molecular links between inflammation and coagulation are unquestioned. Inflammation
promotes coagulation by leading to intravascular tissue factor expression, eliciting the …

Objective To review the mechanisms of action and rationale for the use of recombinant
human activated protein C in the treatment of severe sepsis. Specifically, we focus on the …

Background The protein C anticoagulant pathway is critical to the control of hemostasis.
Thrombomodulin and a newly identified receptor for protein C/activated protein C, EPCR …