Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor

JK Bonnington, PA McNaughton - The Journal of physiology, 2003 - Wiley Online Library
Nerve growth factor (NGF) causes a rapid sensitisation of nociceptive sensory neurones to
painful thermal stimuli owing to an action on the heat and capsaicin receptor TRPV1 …

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

X Shu, LM Mendell - Neuroscience letters, 1999 - Elsevier
Perforated patch clamp recordings were made from 118 voltage clamped (− 60 mV),
capsaicin-responsive dorsal root ganglion (DRG) cells (< 30 μ) maintained in dissociated …

Neurotrophins and hyperalgesia

XQ Shu, LM Mendell - … of the National Academy of Sciences, 1999 - National Acad Sciences
Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of
nociceptive neurons during development. Recently, it has been shown to play an important …

NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels

X Zhang, J Huang, PA McNaughton - The EMBO journal, 2005 - embopress.org
Nociceptors, or pain‐sensitive receptors, are unique among sensory receptors in that their
sensitivity is increased by noxious stimulation. This process, called sensitization or …

Role of nerve growth factor in pain

K Mizumura, S Murase - Pain control, 2015 - Springer
Nerve growth factor (NGF) was first identified as a substance that is essential for the
development of nociceptive primary neurons and later found to have a role in inflammatory …

Persistent nociception triggered by nerve growth factor (NGF) is mediated by TRPV1 and oxidative mechanisms

MA Eskander, S Ruparel, DP Green… - Journal of …, 2015 - Soc Neuroscience
Nerve growth factor (NGF) is elevated in certain chronic pain conditions and is a sufficient
stimulus to cause lasting pain in humans, but the actual mechanisms underlying the …

Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult …

TD Wilson-Gerwing, MV Dmyterko… - Journal of …, 2005 - Soc Neuroscience
Neurotrophin-3 (NT-3) negatively modulates nerve growth factor (NGF) receptor expression
and associated nociceptive phenotype in intact neurons, suggesting a beneficial role in …

Primary afferent nociceptor mechanisms mediating NGF‐induced mechanical hyperalgesia

M Malik‐Hall, OA Dina… - European Journal of …, 2005 - Wiley Online Library
The underlying mechanism for nerve growth factor (NGF) evoked pain and long‐lasting
mechanical hyperalgesia remains poorly understood. Using intrathecal antisense against …

Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons

J Winston, H Toma, M Shenoy, PJ Pasricha - Pain, 2001 - Elsevier
Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to
capsaicin of a subset of dorsal root ganglion neurons, which express the high-affinity NGF …

Effects of trkB and trkC neurotrophin receptor agonists on thermal nociception: a behavioral and electrophysiological study

XQ Shu, A Llinas, LM Mendell - Pain, 1999 - journals.lww.com
Abstract Nerve-growth factor (NGF), a member of the neurotrophin family, plays an important
role in nociceptor function. Prompted by a previous unexpected finding that NT-4/5, as well …