Regulation of non‐infectious lung injury, inflammation, and repair by the extracellular matrix glycosaminoglycan hyaluronan
An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …
Hyaluronan in tissue injury and repair
A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …
Hyaluronan and its interactions with immune cells in the healthy and inflamed lung
Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …
pericellular matrices. While the production of hyaluronan is essential for mammalian …
Hyaluronan–a functional and structural sweet spot in the tissue microenvironment
J Monslow, P Govindaraju, E Puré - Frontiers in immunology, 2015 - frontiersin.org
Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …
The rise and fall of hyaluronan in respiratory diseases
ME Lauer, RA Dweik, S Garantziotis… - International journal of …, 2015 - Wiley Online Library
In normal airways, hyaluronan (HA) matrices are primarily located within the airway
submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following …
submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following …
Hyaluronan: is bigger better?
TD Camenisch, JA McDonald - American journal of respiratory cell …, 2000 - atsjournals.org
Hyaluronan (HA) is a polymer of molecular mass from 2 105 to 10 106 comprising repeating
disaccharide units of glucuronic acid and N-acetyl-D-glucosamine. HA is abundant, present …
disaccharide units of glucuronic acid and N-acetyl-D-glucosamine. HA is abundant, present …
Role of hyaluronan and hyaluronan-binding proteins in lung pathobiology
FE Lennon, PA Singleton - American Journal of Physiology …, 2011 - journals.physiology.org
Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …
Hyaluronan fragments as mediators of inflammation in allergic pulmonary disease
Asthma is frequently caused and/or exacerbated by sensitization to allergens, which are
ubiquitous in many indoor and outdoor environments. Severe asthma is characterized by …
ubiquitous in many indoor and outdoor environments. Severe asthma is characterized by …
Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity
A Hoarau, M Polette, C Coraux - Biomolecules, 2022 - mdpi.com
Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …
Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury
Background Several inflammatory lung diseases display abundant presence of hyaluronic
acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the …
acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the …