An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …

A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …

Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

In normal airways, hyaluronan (HA) matrices are primarily located within the airway
submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following …

Hyaluronan (HA) is a polymer of molecular mass from 2 105 to 10 106 comprising repeating
disaccharide units of glucuronic acid and N-acetyl-D-glucosamine. HA is abundant, present …

Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …

Asthma is frequently caused and/or exacerbated by sensitization to allergens, which are
ubiquitous in many indoor and outdoor environments. Severe asthma is characterized by …

Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …

Background Several inflammatory lung diseases display abundant presence of hyaluronic
acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the …