Differential killing of the patient's cancer cells versus normal cells is a necessity for
chemotherapy. Advantage can be taken of close regulations of gene expression and of …

Cancer is a disease of “outlaw” cells that become mutated in regulatory mechanisms. They
have lost normal self controls and relationships to the whole organism. Cancers can …

Cell death is a physiological process which is required for normal development and
existence of multi‐cellular organisms. Physiological cell death, or apoptosis, is controlled by …

Cells can die either by apoptosis, necrosis or by a form of cell death that displays
morphologic characteristics of both forms (Los et al., 2002; Proskuryakov et al, 2002; …

The regulatory mechanisms of cell survival and apoptosis are very complex in nature,
implicating numerous players and signaling pathways not only in the decision-making …

We propose that deregulation of proliferation, together with a reduction in apoptosis, creates
a platform that is both necessary and can be sufficient for cancer. The secondary traits of …

Apoptosis can be described as multiple pathways converging from numerous different
initiating events and insults, such as anticancer agents. These pathways converge on a …

Cell growth is referred to as cell proliferation, that is, the increase in cell numbers during
repeated cell division. Cell growth can be defined as the enlargement of cell volume, which …

In developing new and more successful therapies for preventing and treating cancer, it is
critical to understand what normally regulates cell proliferation and cell death and what are …

Recently there have been many advances in the understanding of the genetic basis of
development and regular breakthroughs are being made in the field of tumour cell targeting …