his paper briefly reviews studies on the genes that control the cell division process in human
cancerogenesis. It describes the key biochemical events of the division cycle, their …

The body of knowledge concerning apoptosis and the molecular mechanisms involved in
this cellular process continues to expand at an unprecedented rate. This knowledge has …

The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK), H.
Robert Horvitz (US) and John E. Sulston (UK)" for their discoveries concerning genetic …

During the last decades, the knowledge of cell death mechanisms involved in anticancer
therapy has grown exponentially. However, in many studies, cell death is still described in …

A published microarray gene expression database containing data on 174 tumor samples
from ten tissues was mined, enabling the identification of classes of genes whose …

Tumors frequently acquire resistance to apoptosis that is expected to contribute to malignant
phenotype and reduce sensitivity to treatment. In fact, inactivation of p53 tumor suppressor …

It has long been apparent that alterations in the control of the cell cycle accompany the
development of tumorigenicity. The mere observation that cell growth continues in tumors …

The linchpin to the development of new types of anticancer treatment is the establishment of
experimental models that accurately mimic events of human pathophysiology. Let us recall …