Heterogeneous hydrolytic features for OXA-48-like β-lactamases

S Oueslati, P Nordmann, L Poirel - Journal of Antimicrobial …, 2015 - academic.oup.com
Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are
increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins …

OXA-48-like carbapenemases: the phantom menace

L Poirel, A Potron, P Nordmann - Journal of Antimicrobial …, 2012 - academic.oup.com
Abstract OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly
reported in enterobacterial species. To date, six OXA-48-like variants have been identified …

OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins

L Poirel, M Castanheira, A Carrër… - Antimicrobial agents …, 2011 - Am Soc Microbiol
ABSTRACT Two bla OXA-48-like-positive isolates (Klebsiella pneumoniae and Enterobacter
cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on …

Genetic and biochemical characterization of OXA-405, an OXA-48-type extended-spectrum β-lactamase without significant carbapenemase activity

L Dortet, S Oueslati, K Jeannot, D Tandé… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The epidemiology of carbapenemases worldwide is showing that OXA-48 variants are
becoming the predominant carbapenemase type in Enterobacteriaceae in many countries …

Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae

A Potron, E Rondinaud, L Poirel, O Belmonte… - International journal of …, 2013 - Elsevier
Three enterobacterial isolates (two Klebsiella pneumoniae and one Escherichia coli) were
recovered from three patients transferred from India to France in 2011. All three isolates …

Antimicrobial resistance conferred by OXA-48 β-lactamases: towards a detailed mechanistic understanding

VHA Hirvonen, J Spencer… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
ABSTRACT OXA-48-type β-lactamases are now routinely encountered in bacterial infections
caused by carbapenem-resistant Enterobacterales. These enzymes are of high and growing …

OXA-17, a Further Extended-Spectrum Variant of OXA-10 β-Lactamase, Isolated from Pseudomonas aeruginosa

F Danel, LMC Hall, B Duke, D Gur… - Antimicrobial agents …, 1999 - Am Soc Microbiol
Pseudomonas aeruginosa isolates 871 and 873 were isolated at Hacettepe University
Hospital in Ankara and were highly resistant to ceftazidime (MIC, 128 μg/ml). Each produced …

Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter …

JM Mitchell, JR Clasman, CM June, KCJ Kaitany… - Biochemistry, 2015 - ACS Publications
The carbapenem-hydrolyzing class D β-lactamases OXA-23 and OXA-24/40 have emerged
worldwide as causative agents for β-lactam antibiotic resistance in Acinetobacter species …

Structural basis for different substrate profiles of two closely related class D β-lactamases and their inhibition by halogens

V Stojanoski, DC Chow, B Fryszczyn, L Hu… - Biochemistry, 2015 - ACS Publications
OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different
substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime …

OXA-35 is an OXA-10-related β-lactamase from Pseudomonas aeruginosa

D Aubert, L Poirel, A Ben Ali… - Journal of …, 2001 - academic.oup.com
Pseudomonas aeruginosa clinical isolate PA35 is resistant to amino-and ureido-penicillins,
has intermediate susceptibility to cefsulodin, cefepime and aztreonam, and is susceptible to …