Background Bacterial colonization in cystic fibrosis (CF) lungs has been directly associated
to the loss of CFTR function, and/or secondarily linked to repetitive cycles of chronic …

Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that
predisposes airways to bacterial infection. Advanced CF is characterized by a deficit in …

Cystic fibrosis (CF), an autosomal genetic disorder caused by the dysfunction of the cystic
fibrosis transmembrane conductance regulator (CFTR) protein, is characterized by mucus …

Cystic fibrosis (CF) lung disease is the major cause of morbidity and mortality in people with
CF. Abnormal mucociliary transport has been the leading hypothesis for the underlying …

Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance
regulator (CFTR), an anion channel found mainly in apical membranes of epithelial cells. CF …

Abnormalities in mucus properties and clearance make a major contribution to the pathology
of cystic fibrosis (CF). Our aim was to test the hypothesis that the defects in CF mucus are a …

Most cystic fibrosis (CF) patients die of lung failure, due to the combined effects of bacterial
infection, neutrophil-mediated inflammation, and airway obstruction by hyperviscous mucus …

Normal airways below the carina maintain an essentially sterile environment via a multi-
pronged innate defence system that includes mucus clearance via mucociliary clearance …

Malfunction of the cell surface glycoprotein, cystic fibrosis transmembrane conductance
regulator, is the molecular hallmark of cystic fibrosis (CF), causing salt imbalance across the …

Mucociliary clearance (MCC) and submucosal glands are major components of airway
innate immunity that have impaired function in cystic fibrosis (CF). Although both of these …