The crucial roles of oxidative stress and inflammation in the development of hepatic
diseases have been unraveled and emphasized for decades. From steatosis to fibrosis …

Oxidative stress has been implicated in the etiology of neurodegenerative disease, cancer
and aging. Indeed, accumulation of reactive oxygen and nitrogen species generated by …

Induction of CYP2E1 by ethanol is one pathway through which ethanol generates oxidative
stress. Nrf2 is a transcription factor that regulates important antioxidant and phase II …

Living organisms come under attack from multiple environmental factors, which can lead to
the production of reactive oxygen species (ROS) and electrophiles. This results in oxidative …

Liver regeneration can be impaired by permanent oxidative stress and activation of nuclear
factor erythroid 2-related factor 2 (Nrf2), known to regulate the cellular antioxidant response …

Reactive oxygen species-(ROS-) induced oxidative stress has been implicated in various
forms of diseases. Excessive ROS generation depletes the endogenous antioxidants that …

Hepatocellular carcinoma (HCC), one of the most frequent and deadliest cancers, has been
increasing considerably in the United States. In the absence of a proven effective therapy for …

Drug-induced liver toxicity is the most frequent cause of acute liver failure worldwide.
Hepatotoxicity caused by acetaminophen (ACT) overdose is mediated by its metabolic …

抄録 The gastrointestinal tract is exposed to a variety of noxious factors, such as
Helicobacter pylori, nonsteroidal anti-inflammatory drugs, gastric acid, ischemia-reperfusion …

Abstract Background The transcription factor Nrf2 regulates expression of multiple cellular
defence proteins through the antioxidant response element (ARE). Nrf2-deficient mice …