Liver diseases are a worldwide medical problem because the liver is the principal
detoxifying organ and maintains metabolic homeostasis. The liver metabolizes various …

Nuclear factor-E2-related factor 2 (Nrf2) is known as a key regulator of ARE-mediated gene
expression and the induction of Phase II detoxifying enzymes and antioxidant enzymes …

Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …

Quercetin, one of the most abundant dietary flavonoids, is reported to have protective
function against various hepatotoxicant-induced hepatotoxicity. The present study aims to …

Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance
to oxidants, serves as one of the key defensive factors against a range of pathological …

Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

The transcription factor Nrf2 regulates expression of multiple cellular defence proteins
through the antioxidant response element (ARE). Nrf2-deficient mice (Nrf2−/−) are highly …

Lansoprazole is a potent anti-gastric ulcer drug that inhibits gastric proton pump activity. We
identified a novel function for lansoprazole, as an inducer of anti-oxidative stress responses …

Background & Aims: The transcription factor nuclear factor-eythroid 2–related factor 2
(Nrf2−/−) is essential for protecting cells against xenobiotic and oxidative stress. Increased …

Instances of sustained oxidative activity have been shown to involve dysregulation of Nrf2-
mediated transcriptional induction; however, mechanisms warranting Nrf2-repression …