The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Hepatic stellate cells (HSC) are the key fibrogenic cells of the liver. HSC activation is a
process of cellular transdifferentiation that occurs upon liver injury, but the mechanisms …

Hepatic fibrosis (HF) is a wound-healing response that occurs during chronic liver injury and
features by an excessive accumulation of extracellular matrix (ECM) components. Activation …

Oxidative stress is caused by an imbalance of reactive oxygen species (ROS)/reactive
nitrogen species (RNS) and the antioxidative stress defense systems in cells. ROS/RNS or …

Oxidative stress and lipid accumulation play important roles in alcohol-induced liver injury.
Previous reports showed that, in livers of nuclear factor erythroid 2-related factor 2 (Nrf2) …

The cytoprotective mechanisms of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis
(PBC) have not been fully clarified. UDCA has some antioxidant properties. Nuclear factor …

Oxidative stress is importantly involved in the pathophysiology of various liver diseases. The
redox state participates on the course of the inflammatory, metabolic and proliferative liver …

Redox balance is essential to maintain the body's normal metabolism. Once disrupted, it
may lead to various chronic diseases, such as diabetes, neurodegenerative diseases …

Hepatotoxicity induced by cyclophosphamide (Cyclo) is a major concern in clinical practice.
This study was designed to investigate the possible cytoprotective effect of natural …

Abstract Aims: Angiotensin II (Ang II) aggravates hepatic fibrosis by inducing NADPH
oxidase (NOX)-dependent oxidative stress. Angiotensin-(1–7)[Ang-(1–7)], which counter …