The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism
EE Vomhof-DeKrey, MJ Picklo Sr - The Journal of nutritional biochemistry, 2012 - Elsevier
The nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that responds to
oxidative stress by binding to the antioxidant response element (ARE) in the promoter of …
oxidative stress by binding to the antioxidant response element (ARE) in the promoter of …
Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
Aim Nuclear factor-erythroid 2-related factor-2 (Nrf2) acts as a defense system in the
development of nonalcoholic steatohepatitis (NASH). Curcumin is a phenolic compound …
development of nonalcoholic steatohepatitis (NASH). Curcumin is a phenolic compound …
[HTML][HTML] The Nrf2 system as a potential target for the development of indirect antioxidants
KA Jung, MK Kwak - Molecules, 2010 - mdpi.com
Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …
lipids, and is implicated in various human diseases including cancer, neurodegeneration …
[PDF][PDF] Macrophage nuclear factor erythroid 2‐related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA …
J Rao, J Qiu, M Ni, H Wang, P Wang, L Zhang… - …, 2022 - Wiley Online Library
Abstract Background and Aims Nuclear factor erythroid 2‐related factor 2 (Nrf2) is a master
regulator of reactive oxygen species (ROS) and inflammation and has been implicated in …
regulator of reactive oxygen species (ROS) and inflammation and has been implicated in …
[HTML][HTML] Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy
JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
J Kim, YN Cha, YJ Surh - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a
central role in cellular defense against oxidative and electrophilic insults by timely induction …
central role in cellular defense against oxidative and electrophilic insults by timely induction …
[HTML][HTML] Keap1/Nrf2 signaling pathway
GP Sykiotis - Antioxidants, 2021 - mdpi.com
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-
like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous …
like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous …
[HTML][HTML] Cyanate induces oxidative stress injury and abnormal lipid metabolism in liver through Nrf2/HO-1
L Hu, K Tian, T Zhang, CH Fan, P Zhou, D Zeng… - Molecules, 2019 - mdpi.com
Chronic kidney disease (CKD) is problem that has become one of the major issues affecting
public health. Extensive clinical data suggests that the prevalence of hyperlipidemia in CKD …
public health. Extensive clinical data suggests that the prevalence of hyperlipidemia in CKD …
Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes
JH Yang, BY Shin, JY Han, MG Kim, JE Wi… - Toxicology and applied …, 2014 - Elsevier
Abstract Isorhamentin is a 3′-O-methylated metabolite of quercetin, and has been reported
to have anti-inflammatory and anti-proliferative effects. However, the effects of isorhamnetin …
to have anti-inflammatory and anti-proliferative effects. However, the effects of isorhamnetin …
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine-and choline-deficient diet
YKJ Zhang, RL Yeager, Y Tanaka… - Toxicology and applied …, 2010 - Elsevier
Oxidative stress has been proposed as an important promoter of the progression of fatty liver
diseases. The current study investigates the potential functions of the Nrf2–Keap1 signaling …
diseases. The current study investigates the potential functions of the Nrf2–Keap1 signaling …