Two miRNA clusters reveal alternative paths in late-stage reprogramming
RJ Parchem, J Ye, RL Judson, MF LaRussa… - Cell stem cell, 2014 - cell.com
Ectopic expression of specific factors such as Oct4, Sox2, and Klf4 (OSK) is sufficient to
reprogram somatic cells into induced pluripotent stem cells (iPSCs). In this study, we …
reprogram somatic cells into induced pluripotent stem cells (iPSCs). In this study, we …
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
F Anokye-Danso, CM Trivedi, D Juhr, M Gupta, Z Cui… - Cell stem cell, 2011 - cell.com
Transcription factor-based cellular reprogramming has opened the way to converting
somatic cells to a pluripotent state, but has faced limitations resulting from the requirement …
somatic cells to a pluripotent state, but has faced limitations resulting from the requirement …
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network
Reprogramming of somatic cells to a pluripotent state via expression of Oct4, Klf4, Myc, and
Sox2 is a multistep process involving phased changes in gene expression. Here, we focus …
Sox2 is a multistep process involving phased changes in gene expression. Here, we focus …
Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency
Enforced ectopic expression of a cocktail of pluripotency-associated genes such as Oct4,
Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells …
Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells …
[HTML][HTML] Role of the murine reprogramming factors in the induction of pluripotency
R Sridharan, J Tchieu, MJ Mason, R Yachechko… - Cell, 2009 - cell.com
Induced pluripotent stem (iPS) cells can be obtained from fibroblasts upon expression of
Oct4, Sox2, Klf4, and c-Myc. To understand how these factors induce pluripotency, we …
Oct4, Sox2, Klf4, and c-Myc. To understand how these factors induce pluripotency, we …
Zfp296 is a novel, pluripotent-specific reprogramming factor
G Fischedick, DC Klein, G Wu, D Esch, S Höing… - PLoS …, 2012 - journals.plos.org
Expression of the four transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is sufficient to
reprogram somatic cells into induced pluripotent stem (iPSCs). However, this process is …
reprogram somatic cells into induced pluripotent stem (iPSCs). However, this process is …
Reprogramming of human fibroblasts to pluripotency with lineage specifiers
N Montserrat, E Nivet, I Sancho-Martinez, T Hishida… - Cell stem cell, 2013 - cell.com
Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for
the induction of pluripotency in somatic cells, methodologies replacing the original factors …
the induction of pluripotency in somatic cells, methodologies replacing the original factors …
Mechanistic insights into reprogramming to induced pluripotency
Induced pluripotent stem (iPS) cells can be generated from various embryonic and adult cell
types upon expression of a set of few transcription factors, most commonly consisting of …
types upon expression of a set of few transcription factors, most commonly consisting of …
Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
EP Papapetrou, MJ Tomishima… - Proceedings of the …, 2009 - National Acad Sciences
Human-induced pluripotent stem cells (hiPSCs) are generated from somatic cells by ectopic
expression of the 4 reprogramming factors (RFs) Oct-4, Sox2, Klf4, and c-Myc. To better …
expression of the 4 reprogramming factors (RFs) Oct-4, Sox2, Klf4, and c-Myc. To better …
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
During cellular reprogramming, only a small fraction of cells become induced pluripotent
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were …
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were …