The concept of reversing the characteristics of differentiated tissues to pluripotency through
reprogramming was introduced over 50 years ago in the first somatic cell nuclear transfer …

Somatic cell reprogramming is achieved by four reprogramming transcription factors (RTFs),
Oct3/4, Sox2, Klf4, and c-Myc. However, in addition to the induction of pluripotent cells, these …

Somatic cells and pluripotent cells display remarkable differences in most aspects of cell
function. Accordingly, somatic cell reprogramming by exogenous factors requires …

Induced pluripotent stem (iPS) cells can be generated using retroviral vectors expressing
Oct4, Klf4, Sox2, and cMyc. Most prior studies have required multiple retroviral vectors for …

The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by
reprogramming is accompanied by a global remodeling of the epigenome,,,,, resulting in …

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing
four transcription factors: Oct4, Sox2, Klf4, and c-Myc. Here we report that enhancing RA …

Induced pluripotent stem cells (iPSCs) have been derived at low frequencies from different
cell types through ectopic expression of the transcription factors Oct4 and Sox2, combined …

The generation of induced pluripotent stem cells (iPSCs) devoid of permanently integrated
reprogramming factor genes is essential to reduce differentiation biases and artifactual …

The reprogramming of somatic cells into induced pluripotent stem (iPS) cells upon
overexpression of the transcription factors Oct4, Sox2, Klf4 and cMyc is inefficient. It has …

Somatic reprogramming to induced pluripotent stem cells (iPSC) was realized in the year
2006 in mice, and in 2007 in humans, by transiently forced expression of a combination of …