Designing Multi-Antigen Vaccines Against Acinetobacter baumannii Using Systemic Approaches

MJ McConnell, AJ Martín-Galiano - Frontiers in Immunology, 2021 - frontiersin.org
Vaccines and monoclonal antibodies are promising approaches for preventing and treating
infections caused by multidrug resistant Acinetobacter baumannii. However, only partial …

Promising Acinetobacter baumannii Vaccine Candidates and Drug Targets in Recent Years

YC Tan, C Lahiri - Frontiers in Immunology, 2022 - frontiersin.org
In parallel to the uncontrolled use of antibiotics, the emergence of multidrug-resistant
bacteria, like Acinetobacter baumannii, has posed a severe threat. A. baumannii …

Identification of Novel Vaccine Candidates against Multidrug-Resistant Acinetobacter baumannii

DG Moriel, SA Beatson, DJ Wurpel, J Lipman… - PloS one, 2013 - journals.plos.org
Acinetobacter baumannii is an emerging opportunistic bacterium associated with
nosocomial infections in intensive care units. The alarming increase in infections caused by …

[HTML][HTML] Putative novel B-cell vaccine candidates identified by reverse vaccinology and genomics approaches to control Acinetobacter baumannii serotypes

S Beiranvand, A Doosti, SA Mirzaei - Infection, Genetics and Evolution, 2021 - Elsevier
In the last decade, Multi-drug resistance (MDR)-associated infections of Acinetobacter
baumannii have grown worldwide. A cost-effective preventative strategy against this …

Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets

A Hassan, A Naz, A Obaid, RZ Paracha, K Naz… - BMC genomics, 2016 - Springer
Background Acinetobacter baumannii has emerged as a significant nosocomial pathogen
during the last few years, exhibiting resistance to almost all major classes of antibiotics …

Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches

F Shahid, T Zaheer, ST Ashraf, M Shehroz, F Anwer… - Scientific reports, 2021 - nature.com
Abstract Acinetobacter baumannii (A. baumannii), an opportunistic, gram-negative
pathogen, has evoked the interest of the medical community throughout the world because …

Mapping Global Prevalence of Acinetobacter baumannii and Recent Vaccine Development to Tackle It

C Ma, S McClean - Vaccines, 2021 - mdpi.com
Acinetobacter baumannii is a leading cause of nosocomial infections that severely threaten
public health. The formidable adaptability and resistance of this opportunistic pathogen have …

Delineating the Plausible Molecular Vaccine Candidates and Drug Targets of Multidrug-Resistant Acinetobacter baumannii

S Mujawar, R Mishra, S Pawar, D Gatherer… - Frontiers in cellular and …, 2019 - frontiersin.org
Nosocomial infections have become alarming with the increase of multidrug-resistant
bacterial strains of Acinetobacter baumannii. Being the causative agent in~ 80% of the …

Current advances and challenges in the development of Acinetobacter vaccines

W Chen - Human vaccines & immunotherapeutics, 2015 - Taylor & Francis
Acinetobacter baumannii is a major cause of healthcare-associated infections worldwide
with high morbidity and mortality. The clinical treatment of A. baumannii infections has …

Immunoinformatics-guided designing of epitope-based subunit vaccine from Pilus assembly protein of Acinetobacter baumannii bacteria

SR Mahapatra, J Dey, A Jaiswal, R Roy, N Misra… - Journal of …, 2022 - Elsevier
Acinetobacter baumannii, a prominent pathogen responsible for chronic infections in the
blood, urinary tract, and lungs, has a high mortality due to its virulence and limited …