We have previously shown that the balance of electrically evoked descending brainstem
control of spinal nociceptive reflexes undergoes a switch from excitation to inhibition in …

The increase in expression of endogenous opioidergic targets coincides with functional
maturation of pain signalling in the third postnatal week of the rat. ABSTRACT Significant …

The rostroventral medial medulla (RVM) is part of a rapidly acting spino-bulbo-spinal loop
that is activated by ascending nociceptive inputs and drives descending feedback …

Brainstem–spinal cord connections play an essential role in adult pain processing, and the
modulation of spinal pain network excitability by brainstem nuclei is known to contribute to …

The rostral ventromedial medulla (RVM) forms part of a descending pathway that modulates
nociceptive neurotransmission at the level of the spinal cord dorsal horn. However, the …

Opioid compounds have powerful analgesic properties when administered to the spinal
cord. These effects are exerted through mu and delta opioid receptors, and both pre-and …

The rostral ventromedial medulla (RVM) is a major locus for the descending control of
nociception and opioid analgesia. However, it is not clear how opioids affect synaptic inputs …

Budai, Dénes and Howard L. Fields. Endogenous opioid peptides acting at μ-opioid
receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons …

Neurons in the rostroventromedial medulla (RVM) project to spinal loci where the neurons
inhibit or facilitate pain transmission. Abnormal activity of facilitatory processes may thus …

During chronic pain, the supraspinal pain modulatory system undergoes plastic changes
with enhancement of facilitation transmission at the spinal cord. The changes induced by …