Silicosis decreases bone mineral density in rats

Z Hui, X Dingjie, Y Yuan, W Zhongqiu, M Na… - Toxicology and Applied …, 2018 - Elsevier
Silicosis is the most common occupational lung disease in China, and is associated with a
variety of complications, many of which are poorly understood. For example, recent data …

[HTML][HTML] Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica

IN Zelko, J Zhu, JD Ritzenthaler, J Roman - Respiratory research, 2016 - Springer
Background Occupational and environmental exposure to crystalline silica may lead to the
development of silicosis, which is characterized by inflammation and progressive fibrosis. A …

Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions

V Castranova, D Porter, L Millecchia, JYC Ma… - … /Nitrogen Radicals: Cell …, 2002 - Springer
Numerous investigations have been conducted to elucidate mechanisms involved in the
initiation and progression of silicosis. However, most of these studies involved bolus …

Granuloma formation induced by low-dose chronic silica inhalation is associated with an anti-apoptotic response in Lewis rats

RJ Langley, NC Mishra… - Journal of Toxicology …, 2010 - Taylor & Francis
Chronic human silicosis results primarily from continued occupational exposure to silica and
exhibits a long asymptomatic latency. Similarly, continued exposure of Lewis rats to low …

Current concepts in pathogenesis, diagnosis, and management of silicosis and its subtypes

M Salahuddin, Z Cawasji, S Kaur… - Current Pulmonology …, 2021 - Springer
Abstract Purpose of Review Pneumoconiosis due to silicosis is still present due to modern
industries such stone carving, garment industry, and road construction. We aim to discuss …

[HTML][HTML] Biomonitoring exposure and early diagnosis in silicosis: a comprehensive review of the current literature

IM Căluțu, RA Smărăndescu, A Rașcu - Biomedicines, 2022 - mdpi.com
Silicosis is a particular form of lung fibrosis attributable to occupational exposure to
crystalline silica. The occupational exposure to crystalline silica also increases the risk of …

[HTML][HTML] Effect of sex differences in silicotic mice

F Jin, Y Li, X Wang, X Yang, T Li, H Xu, Z Wei… - International Journal of …, 2022 - mdpi.com
Mechanisms of silicosis, caused by the inhalation of silica are still unclear, and the effect of
sex on silicosis has rarely been reported. The purpose of this study was to investigate …

Lipid dysregulation associated with progression of silica-induced pulmonary fibrosis

R Ma, Y Fan, X Huang, J Wang, S Li… - Toxicological …, 2023 - academic.oup.com
Silicosis is an irreversible, progressive, fibrotic lung disease caused by long-term exposure
to dust-containing silica particles at the workplace. Despite the precautions enforced, the …

Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica

F Jin, Y Li, T Li, X Yang, W Cai, S Li, X Gao… - JoVE (Journal of …, 2022 - jove.com
The major cause of silicosis is the inhalation of silica in the occupational environment.
Despite some anatomical and physiological differences, rodent models continue to be an …

Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice

J Guo, N Gu, J Chen, T Shi, Y Zhou, Y Rong… - Archives of …, 2013 - Springer
The inflammation and fibrosis induced by silica dust are considered to be substantial
responses in silicosis progression. Interleukin-1 beta (IL-1β) plays an important role in silica …