Infrared spectromicroscopy of biochemistry in functional single cells

L Quaroni, T Zlateva - Analyst, 2011 - pubs.rsc.org
Over the years Fourier-Transform Infrared (FTIR) spectroscopy has been widely employed in
the structural and functional characterization of biomolecules. The introduction of infrared …

Opportunities for live cell FT-infrared imaging: macromolecule identification with 2D and 3D localization

EC Mattson, E Aboualizadeh, ME Barabas… - International Journal of …, 2013 - mdpi.com
Infrared (IR) spectromicroscopy, or chemical imaging, is an evolving technique that is poised
to make significant contributions in the fields of biology and medicine. Recent developments …

Live single cell analysis using synchrotron FTIR microspectroscopy: development of a simple dynamic flow system for prolonged sample viability

J Doherty, A Raoof, A Hussain, M Wolna, G Cinque… - Analyst, 2019 - pubs.rsc.org
Synchrotron radiation Fourier transform infrared microspectroscopy (SR-microFTIR) of live
biological cells has the potential to provide far greater biochemical and morphological detail …

Infrared spectroscopy as a new tool for studying single living cells: is there a niche?

S Sabbatini, C Conti, G Orilisi… - Biomedical …, 2017 - content.iospress.com
FTIR spectroscopy is an analytical technique widely applied for studying the vibrational
fingerprint of organic compounds. In recent years, it has been applied to many biomedical …

Single-cell analysis using Fourier transform infrared microspectroscopy

J Doherty, G Cinque, P Gardner - Applied Spectroscopy Reviews, 2017 - Taylor & Francis
Fourier transform infrared spectroscopy (FTIR) is a well-established, non-destructive method
of obtaining chemical information from biological samples such as tissues and cells. This …

Infrared microspectroscopy of biochemical response of living cells in microfabricated devices

G Birarda, G Grenci, L Businaro, B Marmiroli… - Vibrational …, 2010 - Elsevier
First experiments demonstrating the suitability of novel microfabricated fluidic devices for
measuring living cells in physiological environment by synchrotron radiation (SR) Fourier …

IR microspectroscopy of live cells

DA Moss, M Keese, R Pepperkok - Vibrational spectroscopy, 2005 - Elsevier
The objective of the present study was to establish the conditions for infrared spectroscopy
of single living cells in cell culture under aqueous media, using a high brilliance synchrotron …

Increased optical pathlength through aqueous media for the infrared microanalysis of live cells

J Doherty, Z Zhang, K Wehbe, G Cinque… - Analytical and …, 2018 - Springer
The study of live cells using Fourier transform infrared spectroscopy (FTIR) and FTIR
microspectroscopy (FT-IRMS) intrinsically yields more information about cell metabolism …

The effect of optical substrates on micro-FTIR analysis of single mammalian cells

K Wehbe, J Filik, MD Frogley, G Cinque - Analytical and bioanalytical …, 2013 - Springer
The study of individual cells with infrared (IR) microspectroscopy often requires living cells to
be cultured directly onto a suitable substrate. The surface effect of the specific substrates on …

Detection of weak absorption changes from molecular events in time-resolved FT-IR spectromicroscopy measurements of single functional cells

L Quaroni, T Zlateva, E Normand - Analytical chemistry, 2011 - ACS Publications
The possibility of performing FT-IR spectromicroscopy experiments on individual living cells
is the focus of considerable attention. Among the applications of interest, the obtainment of …