Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.
CA DeMeester, X Bu, RJ Gray, AJ Lusis… - American journal of …, 1995 - ncbi.nlm.nih.gov
Abstract Lipoprotein (a)(Lp [a]) is a cholesterol-rich lipoprotein resembling LDL but also
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …
containing a large polypeptide designated apolipoprotein (a)(apo [a]). Its levels are highly …
ApoE genotype affects allele-specific apo [a] levels for large apo [a] sizes in African Americans: the Harlem-Basset Studys⃞
E Anuurad, G Lu, J Rubin, TA Pearson… - Journal of lipid …, 2007 - ASBMB
The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and
allele frequencies differ between African Americans and Caucasians. As African Americans …
allele frequencies differ between African Americans and Caucasians. As African Americans …
Polymorphisms in the apolipoprotein (a) gene and their relationship to allele size and plasma lipoprotein (a) concentration
LH Puckey, RM Lawn, BL Knight - Human molecular genetics, 1997 - academic.oup.com
Genotypes at five previously described polymorphic sites at the apolipoprotein (a) gene
locus have been determined for the members of 27 families as well as for unrelated white …
locus have been determined for the members of 27 families as well as for unrelated white …
Studies on apolipoprotein (a) phenotypes. Part 2. Phenotype frequencies and Lp (a) concentrations in different phenotypes in patients with angiographically defined …
A Abe, A Noma, YJ Lee, H Yamaguchi - Atherosclerosis, 1992 - Elsevier
In the present paper, we have evaluated serum Lp (a) concentrations, the frequencies of Lp
(a) phenotypes and alleles and the association between the Lp (a) phenotypes and serum …
(a) phenotypes and alleles and the association between the Lp (a) phenotypes and serum …
Comparative analysis of the apo (a) gene, apo (a) glycoprotein, and plasma concentrations of Lp (a) in three ethnic groups. Evidence for no common
A Gaw, E Boerwinkle, JC Cohen… - The Journal of Clinical …, 1994 - Am Soc Clin Investig
Distributions of plasma lipoprotein (a)(Lp [a]) concentrations exhibit marked interracial
differences. Apolipoprotein (a)(apo [a]), the unique constituent of Lp (a), is highly …
differences. Apolipoprotein (a)(apo [a]), the unique constituent of Lp (a), is highly …
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …
JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …
explain between-population variations in phenotypes is unknown. The heritable coronary …
Apolipoprotein (a) phenotypes, Lp (a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the …
CH Sandholzer, E Boerwinkle, N Saha… - The Journal of …, 1992 - Am Soc Clin Investig
Elevated lipoprotein (a)(Lp [a]) concentrations are associated with premature coronary heart
disease (CHD). In the general population, Lp (a) levels are largely determined by alleles at …
disease (CHD). In the general population, Lp (a) levels are largely determined by alleles at …
Lipoprotein (a) in health and disease
F Kronenberg, A Steinmetz, GM Kostner… - Critical reviews in …, 1996 - Taylor & Francis
Abstract Lipoprotein (a)[Lp (a)] represents an LDL-like particle to which the Lp (a)-specific
apolipoprotein (a) is linked via a disulfide bridge. It has gained considerable interest as a …
apolipoprotein (a) is linked via a disulfide bridge. It has gained considerable interest as a …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Apolipoprotein (a) polymorphism and its association with plasma lipoprotein (a) levels: a north Indian study.
S Vasisht, R Gulati, LM Srivastava, R Narang… - Indian Heart …, 2000 - europepmc.org
Elevated levels of lipoprotein (a) has been regarded as an independent risk factor for
coronary, peripheral and cerebral atherosclerosis. The enormous intra-personal variation in …
coronary, peripheral and cerebral atherosclerosis. The enormous intra-personal variation in …