Objectives: To clarify the role of renal tubular cell (RTC) injury and oxidative stress in the
early stage of renal calcium oxalate crystal formation in a mouse model. Methods: Daily intra …

Crystal formation in mice could not be induced either by the administration of ethylene glycol
or by glycolate. To clarify the reasons for the difference among these oxalate precursors in …

Background: Peroxidation of renal cells is a critical event in the nucleation and formation of
calcium oxalate crystals under hyperoxaluric conditions. We previously demonstrated that …

Purpose: Oxalate and calcium oxalate (CaOx) crystals are injurious to renal epithelial cells.
The injury is caused by the production of reactive oxygen species (ROS). Citrate is a well …

Objective To investigate whether calcium oxalate monohydrate (COM), a key element of
hyperoxaluria, would induce renal cell injury through oxidative stress and also whether …

Abstract Purpose: Calcium oxalate (CaOx) is one of the key elements for kidney stone
formation, but the exact mechanism needs to be defined. CaOx has been shown to cause …

We previously reported that oxidative stress and renal tubular damage occur in chronic
hyperoxaluric rats. However, the in vivo responses of renal epithelial cells after vitamin E …

Since hypercalciuria is a common feature of idiopathic calcium oxalate (CaOx)
nephrolithiasis, renal epithelial cells of stone patients are exposed to various crystals in the …

Exposure to high levels of oxalate and calcium oxalate monohydrate (COM) crystals is
injurious to renal epithelial cells and triggers serial responses related to stone formation …

Calcium oxalate monohydrate (COM) crystals are the commonest component of kidney
stones. Oxalate and COM crystals in renal cells are thought to contribute to pathology via …