Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls

AS Rao, M Camilleri, DJ Eckert… - American Journal …, 2011 - journals.physiology.org
Mucosal barrier dysfunction contributes to gastrointestinal diseases. Our aims were to
validate urine sugar excretion as an in vivo test of small bowel (SB) and colonic permeability …

[HTML][HTML] Development and validation of test for “leaky gut” small intestinal and colonic permeability using sugars in healthy adults

K Khoshbin, L Khanna, D Maselli, J Atieh… - Gastroenterology, 2021 - Elsevier
Background Oral monosaccharides and disaccharides are used to measure in vivo human
gut permeability through urinary excretion. Aims The aims were as follows:(1) to obtain …

Gastrointestinal permeability in patients with irritable bowel syndrome assessed using a four probe permeability solution

AY Del Valle-Pinero, HE Van Deventer, NH Fourie… - Clinica Chimica …, 2013 - Elsevier
BACKGROUND: Abnormal gastrointestinal permeability has been linked to irritable bowel
syndrome (IBS). The lactulose-to-mannitol ratio is traditionally used to assess small intestine …

Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial

K van Wijck, TJM Verlinden, HMH van Eijk, J Dekker… - Clinical nutrition, 2013 - Elsevier
BACKGROUND & AIMS: Increased gastrointestinal (GI) permeability is an important
hallmark of many conditions, potentially leading to antigen exposure and sepsis. Current …

Novel analytical approach to a multi-sugar whole gut permeability assay

K van Wijck, HMH van Eijk, WA Buurman… - … of Chromatography B, 2011 - Elsevier
Many pathophysiological conditions are associated with increased gastrointestinal
permeability, reflecting an elevated risk of endotoxaemia, inflammation, and sepsis …

Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to …

Z Mujagic, S Ludidi, D Keszthelyi… - Alimentary …, 2014 - Wiley Online Library
Background Intestinal permeability has been studied in small groups of IBS patients with
contrasting findings. Aims To assess intestinal permeability at different sites of the GI tract in …

Biomarkers for assessment of intestinal permeability in clinical practice

B Seethaler, M Basrai, AM Neyrinck… - American Journal …, 2021 - journals.physiology.org
Intestinal permeability is an important diagnostic marker, yet its determination by established
tests, which measure the urinary excretion of orally administered tracer molecules, is time …

Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion

M Camilleri, A Nadeau, J Lamsam… - …, 2010 - Wiley Online Library
Our aim was to understand the information from differential two‐sugar excretion (2‐SE) in
measuring intestinal permeability. In a crossover study in 12 healthy volunteers, we …

Geography of intestinal permeability and absorption

IS Menzies, MJ Zuckerman, WS Nukajam… - Gut, 1999 - gut.bmj.com
BACKGROUND Intestinal morphology and function vary geographically. AIMS These
functions were assessed in asymptomatic volunteers in European, North American, Middle …

Intestinal permeability is decreased in anorexia nervosa

P Monteleone, R Carratu, M Carteni, M Generoso… - Molecular …, 2004 - nature.com
Malnutrition and absence of exogenous luminal nutrients in the gastrointestinal tract affect
intestinal permeability (IP) leading to an increased penetration of substances that passively …