Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

Adenosine A 2A receptors, which have been cloned from several mammalian species, are
activated by physiological concentrations of adenosine to stimulate the formation of cAMP …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

1. Adenosine is an endogenous neuromodulator that exerts its depressant effect on neurons
by acting on the A 1 adenosine receptor subtype. Excitatory actions of adenosine, mediated …

Adenosine A2A receptors were cloned about ten years ago and are known to be well
conserved among mammals. Rather selective agonists and antagonists are available. In …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Adenosine A2B and, much more importantly, adenosine A2A receptors modulate many
physiological and pathological processes in the brain. In this review, the most recent …

Adenosine acts as a neuromodulator through A1 and A2 receptors. The adenosine analogs
have been recognized, among other effects, as strong depressors of the locomotor activity …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …