Medicinal chemistry of adenosine A3 receptor ligands

CE Muller - Current topics in medicinal chemistry, 2003 - ingentaconnect.com
A3 Adenosine receptors (ARs) exhibit large species differences. Potent, selective agonists
for rat (eg Cl-IB-MECA, 5) and human A3 ARs (eg PENECA, 17, and analogs) have been …

Adenosine receptors in neurological disorders

F Impagnatiello, E Bastia, E Ongini… - Emerging Therapeutic …, 2000 - Taylor & Francis
Adenosine is present in the extacellular space of organs and tissues in the mammalian
organism where it modulates a variety of physiological processes through specific cell …

Characterization of the rat A2A adenosine receptor gene: a 4.8‐kb promoter‐proximal DNA fragment confers selective expression in the central nervous system

YC Lee, CL Chien, CN Sun, CL Huang… - European Journal of …, 2003 - Wiley Online Library
We isolated and characterized a 4.8‐kb 5′ flanking region of the rat A2A adenosine
receptor (A2A‐R) gene in the present study. Promoter activity was observed with this DNA …

Highlights on the Development of A2A Adenosine Receptor Agonists and Antagonists

G Cristalli, B Cacciari, D Dal Ben… - ChemMedChem …, 2007 - Wiley Online Library
Although significant progress has been made in the past few decades demonstrating that
adenosine modulates a variety of physiological and pathophysiological processes through …

Binding of the prototypical adenosine A2A receptor agonist CGS 21680 to the cerebral cortex of adenosine A1 and A2A receptor knockout mice

LV Lopes, L Halldner, N Rebola… - British journal of …, 2004 - Wiley Online Library
2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …

Aspects of the general biology of adenosine A2A signaling

BB Fredholm, Y Chern, R Franco, M Sitkovsky - Progress in neurobiology, 2007 - Elsevier
Many of our current hopes of finding better ways to treat Parkinson's disease or to stop its
progression rely on studies of adenosine A2A receptors in the brain. Yet any drug targeting …

Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and …

SA Rivkees, SL Price, FC Zhou - Brain research, 1995 - Elsevier
Polyclonal antisera were generated against two identical regions of rat and human A1
adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western …

Cloning and expression of the A2a adenosine receptor from guinea pig brain

F Meng, G Xie, D Chalmers, C Morgan… - Neurochemical …, 1994 - Springer
A full-length complementary DNA (cDNA) clone encoding the guinea pig brain A 2
adenosine receptor has been isolated by polymerase chain reaction (PCR) and low …

A3 Adenosine Receptor: Pharmacology and Role in Disease

PA Borea, S Gessi, S Bar-Yehuda… - Adenosine receptors in …, 2009 - Springer
The study of the A 3 adenosine receptor (A 3 AR) represents a rapidly growing and intense
area of research in the adenosine field. The present chapter will provide an overview of the …

Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA

A Townsend-Nicholson, J Shine - Molecular brain research, 1992 - Elsevier
Using the sequence conservation in the G protein-coupled receptor superfamily, we have
isolated an adenosine A 1 receptor cDNA from a human hippocampal cDNA library by …