Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four
members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all …

The ability of the extracellular nucleoside adenosine to regulate metabolism has been
intensively studied since the original description of the cardiovascular effects of adenosine …

Adenosine, beside its role in the intermediate metabolism, mediates its physiological
functions by interacting with four receptor subtypes named A1, A2A, A2B and A3. All these …

An interaction between adenosine A 2A and dopamine D 2 receptors has been
demonstrated previously. It is generally found that agonist treatment internalizes receptors …

Abstract A 2A and A 2B adenosine receptors (ARs) are closely related G protein-coupled
receptor subtypes, which represent important (potential) drug targets. Despite their almost …

Adenosine A 2a receptors are not confined to dopamine-rich areas of the brain, since
thermocycling analysis shows that adenosine A 2a receptor mRNA is expressed also in the …

Agonists bind with higher affinity to G protein-coupled heptahelical receptors than to
uncoupled receptors. Recombinant A1 and A3 adenosine receptors couple well to Gi/o, but …

Potent adenosine receptor (AR) agonists and antagonists with high selectivity for the A1AR
subtype have been developed during the past decades. However, some of the compounds …

It has been shown that adenosine deaminase (ADA; EC 3.5. 4.4) behaves as an ecto‐
enzyme anchored to membrane proteins, among them A1 adenosine receptors (A1Rs) …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …