The brain histaminergic system is one of the diffuse modulatory neurotransmitter systems
which regulate neuronal activity in many brain areas. Studies on both rats and mice indicate …

Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish
motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related …

Histamine and its receptors in the nervous system received recognition late in comparison to
the other aminergic transmitters, after the detection of histaminergic neurons in the posterior …

Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC
KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels …

Alcohol use disorder is associated with several mental, physical, and social problems. Its
treatment is difficult and often requires a combination of pharmacological and behavioural …

Rationale Growing evidence supports a role for the central histaminergic system to have a
modulatory influence on drug addiction in general and alcohol-use disorders in particular …

Substance use disorders are a leading cause of morbidity and mortality, and available
pharmacological treatments are of modest efficacy. Histamine is a biogenic amine with four …

Background and Purpose Conflicting data have been published on whether histamine is
inhibitory to the rewarding effects of abused drugs. The purpose of this study was to clarify …

The histaminergic system is thought to regulate brain reward, but the exact mechanisms are
poorly understood. This study aims to reveal the pathophysiological differences in the brain …

We have earlier found that the histamine H3 receptor (H3R) antagonism diminishes
motivational aspects of alcohol reinforcement in mice. Here we studied the role of H3Rs in …