Histamine H 3 receptors inhibit the release of not only histamine itself, but also other
neurotransmitters including dopamine. Previous papers have reported that histaminergic …

Since the cloning of the histamine H3 receptor cDNA in 1999 by Lovenberg and co-workers,
this histamine receptor has gained the interest of many pharmaceutical companies as a …

The discovery of the presynaptic histamine H3 receptors confirmed the idea that histamine is
a neurotransmitter in the mammalian brain. The H3 receptors (autoreceptors) regulate the …

Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic …

The cloning of the H3 receptor gene offers a variety of other possibilities in addition to site-
directed mutagenesis. Recent pharmacological studies suggested H3 receptor …

The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived
interest in histamine research and exposed attractive perspectives for the potential …

Histamine is an important neurotransmitter that contributes to various processes, including
the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated …

The histamine H 3 receptor (H 3 R), belonging to the family of G-protein-coupled receptors,
is predominantly expressed in the central nervous system (CNS). Since its discovery by …

The successful cloning and functional expression of the histamine H3 receptor in the late
1990s has greatly facilitated our efforts to identify small molecule, non-imidazole based …

The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …