Nrf2 is a master transcriptional regulator of antioxidant and cytoprotective pathways.
Currently in its third decade, research on Nrf2 has expanded to encompass not only basic …

One of the most prominent strategies of cancer chemoprevention might be protecting cells or
tissues against various carcinogens and carcinogenic metabolites derived from exogenous …

Since the discovery of AMP-dependent protein kinase (AMPK), its fundamental role in
regulating metabolic pathways and the molecular mechanism underlying the regulation of its …

Abstract Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from
endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided …

Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …

Endothelial dysfunction is an important risk factor for cardiovascular disease, and it
represents the initial step in the pathogenesis of atherosclerosis. Failure to protect against …

Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

The Kelch-like ECH associated protein 1 (Keap1)–NF-E2 p45-related factor 2 (Nrf2)
pathway regulates networks of proteins that protect against the cumulative damage of …