The transcription factor NRF2 plays a key role in the protection against environmental stress
and maintaining cellular homeostasis. The acetyltransferase p300 is a known component of …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

AMP-activated protein kinase (AMPK) is a key regulator of metabolism and survival during
energy stress. Dysregulation of AMPK is strongly associated with oxidative-stress-related …

Nrf2 is the major transcription factor that regulates many of the cytoprotective enzymes
involved in the adaptive stress response. Modulation of Nrf2 could be therapeutically useful …

Abstract NF-E2–related factor 2 (NRF2) transcription factor has a fundamental role in cell
homeostasis maintenance as one of the master regulators of oxidative and electrophilic …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

The Kelch ECH associating protein 1-nuclear factor-E2-related factor 2-antioxidant response
element (Keap 1-Nrf2-ARE) signaling pathway regulates several protective mechanisms …

For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …