Leveraging Aptamer-Based DNA Nanotechnology for Bioanalysis and Cancer Therapeutics

Z Huang, D Wang, Q Zhang, Y Zhang… - Accounts of Materials …, 2024 - ACS Publications
Conspectus Aptamers are single-stranded DNA or RNA molecules composed of 15–80
nucleotides, obtained from a random oligonucleotide library via the systematic evolution of …

Integrating DNA nanotechnology with aptamers for biological and biomedical applications

Z Huang, L Qiu, T Zhang, W Tan - Matter, 2021 - cell.com
In addition to critical biological roles, DNA is also considered an excellent engineering
material with unique characteristics of high programmability and addressability. Recent …

Current advances in aptamers for cancer diagnosis and therapy

S Hori, A Herrera, JJ Rossi, J Zhou - Cancers, 2018 - mdpi.com
Nucleic acid aptamers are single-stranded oligonucleotides that interact with target
molecules with high affinity and specificity in unique three-dimensional structures. Aptamers …

Nucleic acid aptamers in cancer research, diagnosis and therapy

H Ma, J Liu, MM Ali, MAI Mahmood… - Chemical Society …, 2015 - pubs.rsc.org
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …

Aptamer-based probes for cancer diagnostics and treatment

X Hu, D Zhang, Z Zeng, L Huang, X Lin, S Hong - Life, 2022 - mdpi.com
Aptamers are single-stranded DNA or RNA oligomers that have the ability to generate
unique and diverse tertiary structures that bind to cognate molecules with high specificity. In …

Aptamers: Promising Reagents in Biomedicine Application

H Zhou, Y Li, W Wu - Advanced Biology, 2024 - Wiley Online Library
Nucleic acid aptamers, often termed “chemical antibodies,” are short, single‐stranded DNA
or RNA molecules, which are selected by SELEX. In addition to their high specificity and …

Materials applications of aptamers

C Fan, S Wang, K Schanze… - ACS Applied Materials & …, 2021 - ACS Publications
Aptamers are a class of functional oligonucleotides that are in vitro selected via systematic
evolution of ligands by exponential enrichment (SELEX). Aptamers can bind a wide range of …

DNA aptamer technology for personalized medicine

H Xing, K Hwang, J Li, SF Torabi, Y Lu - Current opinion in chemical …, 2014 - Elsevier
Highlights•The development of DNA aptamers parallels that of personalized medicine.•Both
aptamer-functionalized nanomaterials and DNA nanostructures have been developed.•They …

DNA aptamer based nanodrugs: molecular engineering for efficiency

S Cansiz, L Zhang, C Wu, Y Wu, IT Teng… - Chemistry–An Asian …, 2015 - Wiley Online Library
In the past two decades, the study of cancer therapy has gradually advanced to the “nano”
era. Numerous novel nanomaterials armed with unique physical properties have been …

[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging

M Liu, L Wang, Y Lo, SCC Shiu, AB Kinghorn… - Cells, 2022 - mdpi.com
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …