[HTML][HTML] Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat

O Dali, JA Muriel-Muriel, A Vargas-Baco… - Epigenetics & …, 2024 - Springer
Background Prenatal nicotine exposure (PNE) has been documented to cause numerous
deleterious effects on fetal development. However, the epigenetic changes promoted by …

[HTML][HTML] Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action

A Altintaş, J Liu, O Fabre, TD Chuang… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Perinatal smoke/nicotine exposure alters lung development and causes asthma in exposed
offspring, transmitted transgenerationally. The mechanism underlying the transgenerational …

Paternal cigarette smoke alters DNA methylation in sperm and gene expression in offspring brain

PJ Murphy, J Guo, TG Jenkins, ER James, JR Hoidal… - bioRxiv, 2019 - biorxiv.org
Background There is growing evidence that paternal pre-conception cigarette smoke (CS)
exposure is associated with increased risk of behavioral disorders and cancer in offspring …

Reduced testicular steroidogenesis in rat offspring by prenatal nicotine exposure: Epigenetic programming and heritability via nAChR/HDAC4

Q Zhang, L Pei, M Liu, F Lv, G Chen, H Wang - Food and chemical …, 2020 - Elsevier
Prenatal nicotine exposure (PNE) may lead to offspring's testicular dysplasia. Here, we
confirmed the intergenerational effect of PNE on testosterone synthetic function and …

[HTML][HTML] Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants

DM McCarthy, TJ Morgan Jr, SE Lowe… - PLoS …, 2018 - journals.plos.org
Use of tobacco products is injurious to health in men and women. However, tobacco use by
pregnant women receives greater scrutiny because it can also compromise the health of …

[HTML][HTML] Sperm DNA methylation altered by THC and nicotine: Vulnerability of neurodevelopmental genes with bivalent chromatin

R Schrott, M Rajavel, K Acharya, Z Huang, C Acharya… - Scientific reports, 2020 - nature.com
Men consume the most nicotine and cannabis products but impacts on sperm epigenetics
are poorly characterized. Evidence suggests that preconception exposure to these drugs …

[HTML][HTML] Perinatal exposure to nicotine alters sperm RNA profiles in rats

H Wang, J Liu, J Gao, W Yan, VK Rehan - Frontiers in Endocrinology, 2022 - frontiersin.org
Perinatal exposure to smoking has been associated with childhood asthma, one of the most
common pediatric conditions affecting millions of children globally. Of great interest, this …

In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model

MA Suter, AR Abramovici, E Griffin… - … Research Part A …, 2015 - Wiley Online Library
Background Fetal exposure to nicotine is not limited to maternal tobacco smoke, as
electronic cigarettes have an increased prevalence of use among reproductive aged …

Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis

J Dai, C Zhan, W Xu, Z Wang, D Nie, X Zhao… - …, 2015 - Wiley Online Library
Many studies have addressed the hazardous role of cigarette smoking on male fertility, but
the exact molecular mechanisms involved in the impairments caused by nicotine remain …

Developmental nicotine exposure and masculinization of the rat preoptic area

R Joglekar, M Cauley, T Lipsich, DL Corcoran… - Neurotoxicology, 2022 - Elsevier
Nicotine is a neuroteratogenic component of tobacco smoke, e-cigarettes, and other
products and can exert sex-specific effects in the developing brain, likely mediated through …