A major challenge in the health care system is the lack of knowledge about the possible
harmful effects of multiple drug treatments in old age. The present study aims to characterize …

The potential harmful effects of polypharmacy (concurrent use of 5 or more drugs) are
difficult to investigate in an experimental design in humans. Moreover, there is a lack of …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

A major challenge in health care is the lack of knowledge about effects of multiple drug
treatment—polypharmacy—in old age. Randomized clinical trials typically exclude patients …

Cocaine and ethanol are two commonly co-abused substances; however, the
neuropathology following chronic dual consumption is poorly understood. Neural stem cells …

Polypharmacy (use of≥ 5 drugs) is common in older people but has minimal preclinical or
clinical evidence of safety or efficacy and is associated with adverse outcomes in older …

Although previous research has linked polypharmacy to lower cognitive function in the
general population, we know little about this association among economically challenged …

Today there is a higher prevalence of symptomatic treatment than the causative, and the
clinical signs are atypical, so poly therapy or polypharmacy is inevitable. Unfortunately, very …

Increasing use of drugs in elderly persons has raised concerns about undesirable health
outcomes associated with polypharmacy. It is widely known that polypharmacy increases the …