Psychosis and/or aggression are common problems in dementia, and when severe or
persistent, cause considerable patient distress and disability, caregiver stress, and early …

Background Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer
treatment. Unfortunately, this drug is associated with cognitive impairments in cancer …

Background Ageing, sex and polypharmacy affect physical function. Objectives This mouse
study investigates how ageing, sex and polypharmacy interact and affect grip strength …

Aims Frailty is a complex geriatric syndrome resulting in decreased physiological reserves.
Frailty and polypharmacy are common in older adults and the focus of extensive studies …

Deficits in cognition and performance accompanying age-related neurodegenerative
diseases such as Alzheimer's disease (AD) are closely associated with the impairment of …

Under barrier condition and with ad lib access to food and water, 20 Fischer-344 rats were
chronically treated for 10 months with the benzodiazepine (BDZ) antagonist, flumazenil (FL; …

Background: Currently, a large number of people throughout the world are affected by
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and …

To the editor: The Department of Health & Human Services estimates that by 2030 there will
be 72.1 million individuals 65 or older in the US 1 The prevalence of Mild Cognitive …

Background: Previous studies have shown that cyclic nucleotide phosphodiesterase type 5
(PDE5) inhibition with the drugs sildenafil and vardenafil can enhance spatial performance …

Dementia is a major concern among growing chronic diseases in the aging society and its
association with polypharmacy has not been adequately assessed. The objective of this …