Background Polypharmacy, defined as the concurrent use of≥ 5 medications, increases the
risk of drug-drug and drug-disease interactions as well as non-adherence to drug therapy …

In the last three decades, problems related to aging, multi-morbidity, and polypharmacy
have become a prominent issue in global healthcare. In this study, Polypharmacy is defined …

Background Clinical studies have shown an association between long-term anticholinergic
(AC) drug exposure and Alzheimer's disease (AD) pathogenesis, which has been primarily …

Excessive drugs intake among the elderly population, including self-medication, constitutes
an important public health problem. Polypharmacy may lead to numerous adverse health …

Chlorpyrifos (CPF) is an organophosphate pesticide widely used in intensive agriculture.
Various studies have demonstrated delayed neurotoxic effects in adult mammals after acute …

Background: Polypharmacy (using≥ 5 medications) is associated with poor health
outcomes. Mixed results from past studies surrounding chronic medication use, control of …

Aim: The aim of the present study was to investigate whether polypharmacy correlates with
the risk of dementia in older people. Methods: From representative claims data established …

Objective This meta-analysis explored the relationship between polypharmacy and cognitive
impairment in older adults. Methods We systematically searched for observational studies …

Background There are conflicting reports and a lack of evidence-based data regarding
effects of medications on cognition in cognitively normal older adults. We explored whether …

Etazolate is a phosphodiesterase 4 (PDE4) inhibitor and GABAA receptor modulator that
also stimulates alpha-secretase activity and neurotrophic soluble amyloid precursor protein …